Renal cell carcinoma (3)

CASE : 0062

Diagnosis & discussion


Final diagnosis

Renal cell carcinoma, chromophobe cell type

Diagnosis & discussion

    Renal cell carcinomas account for most renal solid tumors and about 90% of renal malignant tumors. Clear cell carcinoma is the most frequent type (≥70%), followed by papillary renal carcinoma (15-20%), and chromophobe cell carcinoma (6-11%). The other types are spindle cell carcinoma and renal carcinoma accompanied by a cyst.
    On unenhanced CT images, renal carcinoma and the parenchyma have similar low attenuations, but the tumor sometimes has high attenuation, depending on bleeding, necrosis, or calcification in the tumor. Calcification is observed in 25-30% but rarely in small renal carcinomas.
    Chromophobe renal carcinoma shows homogeneously weak enhancement in the corticomedullary phase of contrast-enhanced CT and the attenuation is lower than that of the renal parenchyma in the nephrographic phase or excretory phase. This subtype renal carcinoma is associated with a better prognosis than in the other subtypes.

Contributor: Tetsuo Maeda
Institution: Kobe University Hospital
Country: Japan